Garden of Forking Paths; Mitosis Score / ‘Relational process drawing’

‘Relational process drawing’ is a new approach to drawing ‘natural history’. Rather than focusing on the morphology of the object, these drawings (part of the AHRC funded ‘Representing Biology as Process’ project)focus on the dynamic patterns of the processes of life and draw together relationships between energy, time, movement, and environment at the molecular, cellular, and organismal scale. The processes drawn here are co-dependent and nested: protein folding is essential to cell division (mitosis), which is essential to the development of the embryo of the cell (embryogenesis). Each process is intrinsically and reciprocally related to many others. The artistic view of this delicate, beyond visible, dynamic procedure allows us not only to see scientific data collated into images on a screen but to explore the entire process of cell division in one connected image and to think of it in different terms – as a dance, a score, an energetic form.

Cell division, also called mitosis, occurs in all living things and is a fundamental process for life.  During mitosis, a cell duplicates all of its contents, including its chromosomes, and splits to form two identical daughter cells. Mitosis is facilitated by dynamic protein polymers, filaments termed microtubules, which coalesce into a complex structure – the mitotic spindle. The spindle exerts physical force upon duplicated chromosomes, ultimately facilitating their faithful segregation into two equal complements. This is usually followed by cytokinesis – the physical cleavage of the cell into two, through the constriction of the cell membrane.

Here, we have moved away from the textbook images of cell division that show artificial gaps between phases of activity, to an integrated image of the whole at once. We sit together, artist and scientist, drawing stages – sub-processes within the whole – and asking questions “is it like this?”. Then we take a wider view, aiming to connect the stages. At this point we move outside of traditional structure-function relationships, and we might think of the process as a dance, a musical score, or a changing array of energy. We create a four-dimensional template in which to draw, and this provides a framework in which to represent the relationships that are at play in the process we aim to represent. We imagine cell division like a polyphony, and carefully draw the energy landscapes, the rhythmic organisations, the tunes. The feeling for the process takes centre stage as we revise, redraw and reform, synthesizing our drawings first in pencil and then, later, into colour ). We ask other scientists to ‘read’ the image and they tell us they see cell division. ‘Mitosis Score’ is a new image of cell division, all stages connected in one image, and it reminds us of other organic life forms.

These new images raise their own questions – what is happening in the negative space mid-way through? Can these be answered with traditional science, or with something more holistic? And so we can continue, with untested hypotheses formed through and of drawing, to experiment further in art and science.

This series of drawings are the result of a collaboration with a philosopher of biology, John Dupré and cell biologist, James Wakefield.

Reference: G. Anderson,J.  Dupre and J.G. Wakefield (2019) Philosophy of Biology: Drawing and the dynamic nature of living systems. 8:e46962 DOI: 10.7554/eLife.46962

Garden of Forking Paths; Mitosis Score no.1, 2019. Pencil, watercolour and colour pencil on paper, 35x35cm

Garden of Forking Paths; Mitosis Score no.2, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.3, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.4, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.5, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.6, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.7, 2019. Pencil, watercolour and colour pencil on paper, 18x25cm

Garden of Forking Paths; Mitosis Score no.8, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.9, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.10, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.11, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.12, 2019. Pencil, watercolour and colour pencil on paper, 31x41cm

Garden of Forking Paths; Mitosis Score no.13, 2016. Pencil, watercolour and colour pencil on paper, 31x41cm